- Title
- Neonates born to mothers with preeclampsia exhibit sex-specific alterations in microvascular function
- Creator
- Stark, Michael J.; Clifton, Vicki L.; Wright, Ian M. R.
- Relation
- Pediatric Research Vol. 65, Issue 3, p. 291-295
- Publisher Link
- http://dx.doi.org/10.1203/PDR.0b013e318193edf1
- Publisher
- Lippincott, Williams & Wilkins
- Resource Type
- journal article
- Date
- 2009
- Description
- This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and women with late-onset preeclampsia. For male infants, those born to preeclamptic women had greater microvascular blood flow at 6 h (p < 0.05) with no change over time. Male infants of normotensive women exhibited increasing blood flow with time (p = 0.005). Female infants of preeclamptic mothers exhibited similar blood flow at 6 h of age to females of normotensive mothers, followed by significantly greater blood flow by 72 h (p < 0.001). Altered fetal microvascular structure and function in response to maternal preeclampsia may result in sexually dimorphic patterns of fetal growth and account for alterations in neonatal microvascular adaptation after birth.
- Subject
- preeclampsia; maternal asthma; pregnancy; preterm infants
- Identifier
- uon:7592
- Identifier
- http://hdl.handle.net/1959.13/808064
- Identifier
- ISSN:0031-3998
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